The MILabs OI-microCT scanner enables in vivo and ex vivo imaging by combining high-resolution micro-CT and optical imaging (OI). The micro-CT module offers anatomical imaging with high spatial resolution down to the micrometer range, suitable for visualizing bone, organs, and contrast-enhanced structures.

The optical imaging module supports fluorescence and bioluminescence imaging, with fluorescence being performed in both epi- and transillumination modes. This allows for the detection and quantification of fluorescently and bioluminescently labeled molecules, cells, and probes with high sensitivity.

Co-registration of optical and micro-CT images allows functional and molecular signals to be accurately linked to anatomical information. Images can be reconstructed and corrected for optimal spatial and quantitative analysis.

The OI-microCT is suitable for research into tumor development and metastasis, biodistribution of fluorescent and bioluminescent-labeled tracers, inflammation processes, gene expression, and cell tracking. Measurements can be performed in 2D and 3D modes, with longitudinal follow-up in living animal models.

The ultrasound and photoacoustic imager vevo lazrx (visualsonics) enables high frequency ultrasound in vivo examination with 30 um resolution. Photoacoustic pigments (oxygenated/ deoxygenated hemoglobin, melanin etc.) can be detected in the photoacoustic mode. The ultrasound and photoacoustic images can be corregistered. Photoacoustic examination is suitable for observation of tumour vascularisation, tissue perfussion, local hypoxia, detection of labelled probes, nanoparticles or cells. Measurements can be performed in 2D, 3D and 4D mode.